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KMID : 0338420140290040482
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The Korean Journal of Internal Medicine
2014 Volume.29 No. 4 p.482 ~ p.488
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Effects of pretransplant plasmapheresis and rituximab on recurrence of focal segmental glomerulosclerosis in adult renal transplant recipients
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Park Hoon-Suk
Hong Yuah
Sun In-O
Chung Byung-Ha
Kim Hyung-Wook
Choi Bum-Soon
Park Cheol-Whee
Jin Dong-Chan
Kim Yong-Soo
Yang Chul-Woo
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Abstract
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Background/Aims: Recurrent focal segmental glomerulosclerosis (FSGS) following renal transplantation is relatively common. However, the risk factors and optimal pretransplant treatment preventing recurrence of FSGS remain controversial.
Methods: We retrospectively reviewed 27 adult renal transplant recipients with FSGS over a period of 10 years. We first compared possible risk factors for FSGS recurrence between the recurrence and nonrecurrence groups. Then we evaluated the effect of pretransplant plasmapheresis (PP; n = 4) and PP with rituximab (PP + RTX; n = 5) on recurrence of FSGS after transplantation compared to control patients that were not treated with these modalities.
Results: There were seven recurrences in 27 patients (25.9%), but there were no significant differences in possible risk factors for FSGS recurrence between the two groups. Recurrence rates between patients with pretransplant PP or PP + RTX and control patients were not significantly different (22.2% vs. 27.7%, p > 0.05). There was also no significant difference in recurrence between the pretransplant PP and PP + RTX groups (25% vs. 20%, p > 0.05).
Conclusions: Pretransplant PP or PP + RTX do not significantly decrease the recurrence of FSGS in adult renal transplant candidates.
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KEYWORD
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Rituximab, Plasmapheresis, Glomerulosclerosis, focal segmental, Recurrence, Kidney transplantation
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