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KMID : 0338420140290050620
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The Korean Journal of Internal Medicine
2014 Volume.29 No. 5 p.620 ~ p.629
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The effect of high-dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes
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Ryu Ohk-Hyun
Chung Wan-Kyo
Lee Sung-Wha
Hong Kyung-Soon
Choi Moon-Gi
Yoo Hyung-Joon
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Abstract
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Background/Aims: Recent epidemiological studies revealed a striking inverse relationship between vitamin D levels, glucose intolerance/insulin resistance (IR), and cardiovascular disease. However, few interventional studies have evaluated the effect of vitamin D supplementation on cardiovascular risk, such as IR and arterial stiffness, in diabetes. We investigated the role of vitamin D supplemen-tation on cardiovascular risk in type 2 diabetes patients, including metabolic pa-rameters, IR, and arterial stiffness.
Methods: We enrolled patients who were taking antidiabetic medications or man-aged their diabetes using lifestyle changes. We excluded patients who were taking vitamin D or calcium supplements. We randomized participants into the vitamin D group (cholecalciferol 2,000 IU/day + calcium 200 mg/day, n = 40) or the placebo group (calcium 200 mg/day, n = 41). We compared their IR (homeostasis model of assessment [HOMA]-IR) and arterial stiffness (brachial-ankle pulse wave velocity and radial augmentation index) before and after 24 weeks of intervention.
Results: The baseline characteristics of the two groups were similar. A total of 62 participants (placebo, 30; vitamin D, 32) completed the study protocol. At the end of the study period, the 25-hydroxyvitamin D [25(OH)D] levels were significantly higher in the vitamin D group than in the placebo group (35.4 ± 8.5 ng/mL vs. 18.4 ± 7.3 ng/mL, p < 0.001). There was no difference in HOMA-IR or changes in arte-rial stiffness (placebo, 21, vitamin D, 24) between the groups.
Conclusions: Our data suggest that high-dose vitamin D supplementation might be effective in terms of elevating 25(OH)D levels. However, we identified no ben-eficial effects on cardiovascular risk in type 2 diabetes, including IR and arterial stiffness.
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KEYWORD
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Diabetes mellitus, type 2, Insulin resistance, Vitamin D deficiency, Vascular stiffness
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