|
KMID : 0338420150300020198
|
|
The Korean Journal of Internal Medicine
2015 Volume.30 No. 2 p.198 ~ p.204
|
|
|
Cutoff value of serum procalcitonin as a diagnostic biomarker of infection in end-stage renal disease patients
|
|
:Lee Wan-Soo
:Kang Dae-Woong/:Back Jong-Hun/:Kim Hyun-Lee/:Chung Jong-Hoon/:Shin Byung-Chul
|
|
|
Abstract
|
|
|
Background/Aims: Serum procalcitonin (PCT) levels are low in healthy individuals but are elevated in patients with a serious bacterial infection or sepsis. In this study, we examined the ability of serum PCT concentration to diagnose infections in end-stage renal disease (ESRD) patients, and sought to determine an appropriate threshold level.
Methods: Serum PCT levels were measured in ESRD patients on antibiotic therapy for a suspected bacterial infection (ESRD infection [iESRD] group, n = 21), and compared with those of ESRD patients on hemodialysis with no sign of infection (ESRD control [cESRD] group, n = 20).
Results: The mean serum PCT concentration of the iESRD group was significantly higher than in the cESRD group (2.95 ± 3.67 ng/mL vs. 0.50 ± 0.49 ng/mL, p = 0.006), but serum PCT concentrations did not correlate with severity of infection. The optimized threshold level derived for serum PCT was 0.75 ng/mL, rather than the currently used 0.5 ng/mL; this threshold demonstrated a sensitivity and specificity of 76.2% and 80.0% for infection and 100% and 60.6% for systemic inflammatory response syndrome, respectively, compared with the cutoff of 0.5 ng/mL.
Conclusions: This study suggests that serum PCT at a cutoff value of 0.75 ng/mL is an appropriate indicator of infection in ESRD patients.
|
|
|
KEYWORD
|
|
|
Cut-off value, Kidney failure, chronic, Infection, Procalcitonin
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|
|