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KMID : 0338420150300040506
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The Korean Journal of Internal Medicine
2015 Volume.30 No. 4 p.506 ~ p.514
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Infections after lung transplantation: time of occurrence, sites, and microbiologic etiologies
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:Yun Ji-Hyun
:Lee Sang-Oh/:Jo Kyung-Wook/:Choi Se-Hoon/:Lee Jin-A/:Chae Eun-Jin/:Do Kyung-Hyun/:Choi Dae-Kee/:Choi In-Cheol/:Hong Sang-Bum/:Shim Tae-Sun/:Kim Hyeong-Ryul/:Kim Dong-Kwan/:Park Seung-Il
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Abstract
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Background/Aims: Infections are major causes of both early and late death after lung transplantation (LT). The development of prophylaxis strategies has altered the epidemiology of post-LT infections; however, recent epidemiological data are limited. We evaluated infections after LT at our institution by time of occurrence, site of infections, and microbiologic etiologies.
Methods: All consecutive patients undergoing lung or heart-lung transplantation between October 2008 and August 2014 at our institution were enrolled. Cases of infections after LT were initially identified from the prospective registry database, which was followed by a detailed review of the patients' medical records.
Results: A total of 108 episodes of post-LT infections (56 bacterial, 43 viral, and nine fungal infections) were observed in 34 LT recipients. Within 1 month after LT, the most common bacterial infections were catheter-related bloodstream infections (42%). Pneumonia was the most common site of bacterial infection in the 2- to 6-month period (28%) and after 6 months (47%). Cytomegalovirus was the most common viral infection within 1 month (75%) and in the 2- to 6-month period (80%). Respiratory viruses were the most common viruses after 6 months (48%). Catheter-related candidemia was the most common fungal infection. Invasive pulmonary aspergillosis developed after 6 months. Survival rates at the first and third years were 79% and 73%, respectively.
Conclusions: Although this study was performed in a single center, we provide valuable and recent detailed epidemiology data for post-LT infections. A further multicenter study is required to properly evaluate the epidemiology of post-LT infections in Korea.
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KEYWORD
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Lung transplantation, Infection, Epidemiology
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