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KMID : 0338420150300060829
The Korean Journal of Internal Medicine
2015 Volume.30 No. 6 p.829 ~ p.836
Clinical manifestations of pneumonia according to the causative organism in patients in the intensive care unit
:Lee Jung-Kyu
:Lee Jin-Woo/:Park Young-Sik/:Lee Chang-Hoon/:Yim Jae-Joon/:Yoo Chul-Gyu/:Kim Young-Whan/:Han Sung-Koo/:Lee Sang-Min
Abstract
Background/Aims: Whether the causative organism influences the clinical course of pneumonia in the intensive care unit (ICU) is controversial. We assessed the clinical manifestations and prognosis of pneumonia according to the causative pathogens in patients in a medical ICU.

Methods: A retrospective observational study was performed in a medical ICU. Among 242 patients who were admitted to the ICU, 103 who were treated for pneumonia were analyzed.

Results: The causative pathogen was identified in 50 patients (49.0%); 22 patients (21.6%) had multidrug-resistant (MDR) pathogens. The distribution of causative micro-organisms was Staphylococcus aureus (20%), Pseudomonas species (16%), Klebsiella pneumoniae (14%), and Acinetobacter baumannii (12%). No significant difference in ICU mortality rate, duration of ICU stay, duration of mechanical ventilation, or frequencies of re-intubation and tracheostomy were detected based on the identification of any pathogen. In sub-analyses according to the pneumonia classification, the number of pathogens identified did not differ between pneumonia types, and a higher incidence of identified MDR pathogens was detected in the hospital-acquired pneumonia group than in the community-acquired or healthcare- acquired pneumonia groups. However, the clinical outcomes of pneumonia according to identification status and type of pathogen did not differ significantly between the groups.

Conclusions: Neither the causative micro-organism nor the existence of MDR pathogens in critically ill patients with pneumonia was associated with the clinical outcome of pneumonia, including ICU mortality. This result was consistent regardless of the pneumonia classification.
KEYWORD
Pneumonia, Pathogenicity, Drug resistance, multiple, Intensive care units
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