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KMID : 0338420160310010156
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The Korean Journal of Internal Medicine
2016 Volume.31 No. 1 p.156 ~ p.161
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Amikacin therapy for urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli
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Cho Sung-Yeon
Choi Su-Mi
Park Sun-Hee
Lee Dong-Gun
Choi Jung-Hyun
Yoo Jin-Hong
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Abstract
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Background/Aims: The number of urinary tract infections (UTIs) caused by extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) is increasing. In an outpatient setting, there are limited therapeutic options to treat ESBL-producing pathogens. We evaluated the outcomes of amikacin outpatient parenteral antibiotic therapy (OPAT) for UTIs caused by ESBL-EC in patients not pre-treated with carbapenem.
Methods: We retrospectively evaluated the outcomes of amikacin OPAT for UTIs caused by ESBL-EC.
Results: From November 2011 to October 2012, eight females, who could not be hospitalized for carbapenem treatment, were treated with amikacin OPAT for nine episodes of non-bacteremic ESBL-EC UTIs. Seven of the eight patients had one or more comorbidities. Of the nine UTI cases, three had symptomatic lower UTIs and six had non-bacteremic upper UTIs. In all of the cases, symptomatic and laboratory improvements were observed following amikacin OPAT. One patient showed a delayed relapse with bilateral microabscesses 3 weeks after treatment cessation; however, a clinical and microbiological cure was eventually reached. All of the patients were able to tolerate amikacin OPAT without any significant nephrotoxicity or ototoxicity.
Conclusions: Amikacin OPAT represents a feasible therapeutic option for non-bacteremic UTIs caused by ESBL-EC in settings with limited resources.
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KEYWORD
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Amikacin, Beta-lactamases, Outpatients, Urinary tract infections
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