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KMID : 0338420170320040722
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The Korean Journal of Internal Medicine
2017 Volume.32 No. 4 p.722 ~ p.730
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Clinicopathological characteristics of extremely young Korean multiple myeloma patients: therapeutic implications
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Shin Jung-Hoon
Koh Young-Il
Youk Jeong-Hwan
Kim Mi-So
Kim Byung-Soo
Choi Chul-Won
Sung Hwa-Jung
Park Yong
Yoon Sung-Soo
Kim In-Ho
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Abstract
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Background/Aims: Although multiple myeloma (MM) is typically a disease of the elderly, a certain subset of extremely young patients exists. It is necessary to establish clinicopathological characteristics for this population.
Methods: We reviewed the medical records of MM patients whose age was 40 years or younger at diagnosis.
Results: A total of 32 patients were analyzed (male to female ratio 19:13, median age 37 years). According to International Staging System, 29%, 48%, and 16% were in stage I, II, and III, respectively. Light chain myeloma accounted for 30%. Clinically significant anemia, hypercalcemia, azotemia, and hypoalbuminemia were present in 29%, 28%, 13%, and 28%, respectively. Three or more lytic bone lesions were detected in 45% of the patients, whereas 13% had no lytic bone lesions. Regarding treatment, 79% of patients received autologous hematopoietic stem cell transplantation. After a median follow-up duration of 64 months, the 1-, 3-, and 5-year overall survival (OS) rates were 84%, 62%, and 54%, respectively. The median OS was 61 months for the entire cohort.
Conclusions: In our study, MM patients aged 40 years or younger at diagnosis showed no superior survival compared to those of the moderately elderly patients based on historical data.
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KEYWORD
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Multiple myeloma, Young adult, Hematopoietic stem cell transplantation, Treatment outcome
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