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KMID : 0338420170320050916
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The Korean Journal of Internal Medicine
2017 Volume.32 No. 5 p.916 ~ p.922
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Ileocolonoscopic findings in patients with ankylosing spondylitis: a single center retrospective study
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Ahn Soo-Min
Kim Yong-Gil
Bae Seung-Hyeon
Lim Doo-Ho
Hong Seok-Chan
Park Sang-Hyoung
Lee Chang-Keun
Yoo Bin
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Abstract
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Background/Aims: In some Western countries, up to 50% of patients with ankylosing spondylitis (AS) have subclinical gut inflammation. This study was conducted to evaluate the prevalence and severity of gut inflammation and to determine clinical factors associated with colonic inflammation in Korean AS patients who performed ileocolonoscopy without evidence of established inf lammatory bowel diseases before.
Methods: One hundred and eight AS patients who underwent ileocolonoscopy were included in this study. Patients were divided into two groups based on gross ileocolonoscopic findings; patients with inflammatory lesions, and patients without inflammatory lesions.
Results: Inf lammatory lesions in ileocolonoscopic findings were found in 40 patients. The Ankylosing Spondylitis Disease Activity Score C-reactive protein was higher in the group with inflammatory lesions and gut lesions were found often in the terminal ileum. The risk of inflammatory lesions was higher for AS patients whose symptoms required ileocolonoscopy than for AS patients who underwent routine ileocolonoscopy screening (odds ratio, 3.96). However, abnormal lesions were detected also in 17.6% of the patients who underwent ileocolonoscopy for routine screening and most of them were erosion and ulcer. Among patients with inflammatory lesions (n = 40), 23 showed subclinical gut inflammation associated with AS and 17 were diagnosed finally as Crohn’s disease (n = 12), intestinal tuberculosis (n = 4), and ulcerative colitis (n = 1).
Conclusions: Our findings suggest that ileocolonoscopy might be recommended regularly in AS patients even without gastrointestinal symptoms, especially in the patients with high AS activity.
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KEYWORD
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Spondylitis, ankylosing, Colonoscopy, Inflammatory bowel diseases, Gastrointestinal diseases
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