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KMID : 0338420180330040753
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The Korean Journal of Internal Medicine
2018 Volume.33 No. 4 p.753 ~ p.762
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Prevalence of thyroid nodules and their associated clinical parameters: a large-scale, multicenter-based health checkup study
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Moon Jae-Hoon
Hyun Min-Kyung
Lee Ja-Youn
Shim Jung-Im
Kim Tae-Hyuk
Choi Hoon-Sung
Ahn Hwa-Young
Kim Kyung-Won
Park Do-Joon
Park Young-Joo
Yi Ka-Hee
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Abstract
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Background/Aims: We evaluated the prevalence and characteristics of thyroid nodules detected by thyroid ultrasound (US) at health checkups and the associated clinical parameters.
Methods: A total of 72,319 subjects who underwent thyroid US at three health checkup centers in Korea from January 2004 to December 2010 were included in this study. The correlations between the presence of thyroid nodules and other clinical parameters were analyzed.
Results: The prevalence of thyroid nodules and cysts was 34.2% (n = 24,757). Thyroid nodules were more prevalent in women and older age groups. Among the subjects with thyroid nodules with size information (n = 24,686), 18,833 (76.3%) had nodules measuring ≤ 1.0 cm. Women and older age groups showed higher proportion of larger nodules. Percentage of women, age, body mass index (BMI), waist circumference, body fat composition, blood pressure, and the level of fasting glucose, total cholesterol, and low density lipoprotein cholesterol were higher in the subjects with thyroid nodules compared to those without nodules. The prevalence of metabolic syndrome and overt/subclinical thyrotoxic state was higher in the subjects with thyroid nodules. In the multivariable logistic regression analysis, women, age, BMI, metabolic syndrome, and thyrotoxicosis were independently associated with the presence of thyroid nodules.
Conclusions: The high prevalence of thyroid nodules in people who underwent thyroid US at a health checkup suggests that increased detection of thyroid nodules resulted in an increased prevalence in the general population. However, metabolic disturbances may also have contributed to the increase in thyroid nodule prevalence in Korea.
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KEYWORD
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Thyroid nodule, Ultrasonography, Prevalence, Metabolic syndrome
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