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KMID : 0338420180330040823
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The Korean Journal of Internal Medicine
2018 Volume.33 No. 4 p.823 ~ p.828
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The relationship between anti-C-reactive protein and disease activity in patients with systemic lupus erythematosus
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Son Chang-Nam
Lee Tae-Han
Bang Ji-Hye
Jeong Hye-Jin
Chae Jin-Nyeong
Lee Won-Mok
Kim Ji-Min
Kim Sang-Hyon
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Abstract
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Background/Aims: Anti-C-reactive protein (CRP) antibody has been introduced as a potential biologic marker in Systemic lupus erythematosus (SLE). The aim of study is to evaluate the level of anti-CRP antibody in patients with SLE.
Methods: This study investigated the relationship between levels of anti-CRP antibodies and disease activity markers, such as complement, anti-double-stranded DNA antibody, and SLE disease activity index in 34 patients with SLE.
Results: The serum anti-CRP antibody levels of the patients with SLE were significantly higher than those of the healthy controls (11.3 ± 5.6 μg/mL vs. 9.1 ± 2.8 μg/mL). The percentages of the positive anti-CRP antibody were 52.9% in SLE and 27.8% in controls. Disease duration of SLE showed significant correlation with the anti-CRP antibody (r = 0.234, p = 0.026). However no significant relationship was observed between the levels of anti-CRP antibodies and disease activity markers.
Conclusions: These data show that the anti-CRP antibody levels of the patients with SLE were significantly higher than those of healthy controls. We observed that the presence of the anti-CRP anti-CRP antibody was not associated with disease activity of SLE.
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KEYWORD
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Systemic lupus erythematosus, Anti-C-reactive protein antibody
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