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KMID : 0338420210360020382
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The Korean Journal of Internal Medicine
2021 Volume.36 No. 2 p.382 ~ p.391
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Impaired fasting glucose levels in overweight or obese subjects for screening of type 2 diabetes in Korea
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Lee Jin-Hee
Chon Suk
Cha Seon-Ah
Lim Sun-Young
Kim Kook-Rye
Yun Jae-Seung
Rhee Sang-Youl
Yoon Kun-Ho
Ahn Yu-Bae
Woo Jeong-Taek
Ko Seung-Hyun
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Abstract
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Background/Aims: We examined the concordance rate among fasting plasma glucose (FPG), 2-hour post-challenge glucose (2hr PG), and hemoglobin A1c (HbA1c) in the diagnosis of diabetes in a population with a high-risk for type 2 diabetes mellitus (T2DM) in Korea.
Methods: Among the participants from the Korean Diabetes Prevention Study, individuals with FPG ≥ 100 mg/dL, body mass index (BMI) ≥ 23.0 kg/m2, and no previous history of T2DM were consecutively enrolled after a 75 g glucose tolerance test. We analyzed the differences in the clinical characteristics in subjects with stage 1 (FPG, 100 to 109 mg/dL) and stage 2 (FPG, 110 to 125 mg/dL) impaired fasting glucose (IFG).
Results: Of 1,637 participants, 27.2% had T2DM and 59.3% had IFG and/or impaired glucose tolerance (IGT). The mean age was 55.0 ± 8.1 years and the mean BMI was 26.3 ± 2.7 kg/m2. Based on FPG criteria, 515 (31.4%) and 352 (21.5%) subjects were classified as having stage 1 and stage 2 IFG, respectively. The 19.0% of stage 1 and 43.5% of stage 2 subjects showed 2hr PG levels in the diabetic range. Even for those in the normal FPG range, 63 (9.5%) participants showed a 2hr PG level of ≥ 200 mg/dL. Of 446 subjects with newly-diagnosed diabetes, 340 (76.2%) showed FPG levels < 126 mg/dL.
Conclusions: The oral glucose tolerance test should be actively considered for Korean adults who are overweight or obese with the IFG range (FPG, 100 to 125 mg/ dL) to allow for early detection of diabetes and prompt intervention.
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KEYWORD
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Diabetes mellitus, type 2, Prediabetic state, Impaired fasting glucose, Overweight, Hemoglobin A1c
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