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KMID : 0338420210360041001
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The Korean Journal of Internal Medicine
2021 Volume.36 No. 4 p.1001 ~ p.1013
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Effect of omalizumab as add-on therapy to Quality of Life Questionnaire for Korean Asthmatics (KAQLQ) in Korean patients with severe persistent allergic asthma
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Jung Jae-Woo
Park Hae-Sim
Park Choon-Sik
Cho Sang-Heon
Choi In-Seon S.
Moon Hee-Bom
Kwon Soon-Seog
Yoon Ho-Joo
Park Jung-Won
Lee Jong-Myung
Choi Dong-Chull
Choi Byoung-Whui
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Abstract
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Background/Aims: Omalizumab is the first biologic known to be effective in patients with severe allergic asthma.
Methods: This study was conducted as a multicenter, single-group, open trial to evaluate the improvement in the quality of life with the additional administration of omalizumab for 24 weeks in Korean patients with severe persistent allergic asthma.
Results: Of the 44 patients, 31.8% were men and the mean age was 49.8 ± 11.8 years. A score improvement of 0.5 points or more in the Quality of Life Questionnaire for Korean Asthmatics (KAQLQ) was noted in 50.0% (22/44) of the patinets. In the improved group, the baseline total immunoglobulin E (IgE) level and the amount of omalizumab used were higher, and the day and night asthma symptoms were more severe, compared to those in the non-improved group. According to the Global Evaluation of Treatment Effectiveness, favorable outcomes were found in 78.6% of patients. The Korean asthma control test (p < 0.005) and forced expiratory volume in 1 second % predicted (FEV1%; p < 0.01) improved significantly in patients who received omalizumab treatment, compared to that at week 0, and the total dose of rescue systemic corticosteroids significantly decreased (p < 0.05). The improved group on KAQLQ showed a significant improvement in FEV1% (p < 0.001).
Conclusions: Omalizumab can be considered a biological treatment for Korean patients with severe allergic asthma. It is recommended to consider omalizumab as add-on therapy in patients with high baseline total IgE levels and severe asthma symptoms.
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KEYWORD
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Omalizumab, Quality of life, Republic of Korea, Asthma, Prospective studies
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