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KMID : 0338420210360061486
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The Korean Journal of Internal Medicine
2021 Volume.36 No. 6 p.1486 ~ p.1491
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Can reactogenicity predict immunogenicity after COVID-19 vaccination?
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Hwang Young-Hoon
Song Kyoung-Ho
Choi Yun-Sang
Go Su-Ryeong
Choi Su-Jin
Jung Jong-Tak
Kang Chang-Kyung
Choe Pyoeng-Gyun
Kim Nam-Joong
Park Wan-Beom
Oh Myoung-Don
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Abstract
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Background/Aims: This study aimed to assess the association between local and systemic reactogenicity and humoral immunogenicity after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination.
Methods: Adverse events were prospectively evaluated using an electronic diary in 135 healthy adults who received a SARS-CoV-2 vaccine (AZD1222, AstraZeneca/Oxford, n = 42; or BNT162b2, Pfizer/BioNTech, n = 93). We semi-quantitatively measured anti-S1 immunoglobulin G (IgG) using an enzyme-linked immunosorbent assay at baseline, 3 weeks after the first dose of AZD1222 or BNT162b2, and 2 weeks after the second dose of BNT162b2. We evaluated the association between the maximum grade of local or systemic adverse events and the anti-S1 IgG optical density using multivariate linear regression with adjustment for age, sex, and use of antipyretics.
Results: The median age of the 135 vaccinees was 30 years (36 years in the AZD1222 group and 29 years in the BNT162b2 group) and 25.9% were male (9.5% in the AZD1222 group and 33.3% in the BNT162b2 group). Local and systemic adverse events were generally comparable after the first dose of AZD1222 and the second dose of BNT162b2. The grades of local and systemic adverse events were not significantly associated with anti-S1 IgG levels in the AZD1222 or BNT162b2 group.
Conclusions: Local and systemic reactogenicity may not be associated with humoral immunogenicity after SARS-CoV-2 vaccination.
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KEYWORD
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COVID-19, SARS-CoV-2, Immunogenicity, vaccine, Drug-related side effects and adverse reactions, Enzyme-linked immunosorbent assay
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