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KMID : 0338420210360061492
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The Korean Journal of Internal Medicine
2021 Volume.36 No. 6 p.1492 ~ p.1503
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Clinical influences of anticentromere antibody on primary Sjogren’s syndrome in a prospective Korean cohort
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Park Young-Jae
Lee Jennifer
Koh Jung-Hee
Choe Jung-Yoon
Sung Yoon-Kyoung
Lee Shin-Seok
Kim Ji-Min
Park Sung-Hwan
Kwok Seung-Ki
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Abstract
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Background/Aims: This study was performed to clarify inf luences of anticentromere antibody (ACA) on clinical phenotypes of primary Sjogren’s syndrome (pSS) patients in Korea.
Methods: We assessed 318 patients who met the 2016 American College of Rheumatology/ European League Against Rheumatism classification criteria for pSS. All patients were selected from the Korean Initiative of primary Sjogren’s Syndrome (KISS), a prospective cohort. Among them, 53 patients were positive for ACA, while another 265 patients were not. We compared various clinical data including demographic features, extra-glandular manifestations (EGMs), clinical indices, and laboratory values available from the KISS database between the two groups.
Results: Patients in the ACA-positive pSS group were older (p = 0.042), and had higher xerostomia inventory scores (p = 0.040), whereas glandular dysfunction represented with Schirmer I test was more severe in the ACA-negative group. More frequent Raynaud’s phenomenon and liver involvement (both p < 0.001) and less articular involvement (p = 0.037) were observed among the EGMs in the ACA-positive group. Less frequency of leukopenia (p = 0.021), rheumatoid factor (p < 0.001), anti-Ro/SSA antibody positivity (p < 0.001), and hypergammaglobulinemia (p = 0.006), as well as higher positivity rates of anti-nuclear antibody and anti- topoisomerase antibody (p < 0.001 and p = 0.006, respectively) were found in the laboratory data in the ACA-positive pSS group.
Conclusions: Considering distinct phenotypes in hematological and serological features and EGMs, we should monitor the occurrence of these clinical features among pSS patients with ACA in caution.
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KEYWORD
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Sjogren’s syndrome, Anticentromere antibody, Phenotype
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