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KMID : 0338420220370010096
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The Korean Journal of Internal Medicine
2022 Volume.37 No. 1 p.96 ~ p.108
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HFA-PEFF scores: prognostic value in heart failure with preserved left ventricular ejection fraction
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Egashira Koichi
Sueta Daisuke
Komorita Takashi
Yamamoto Eiichiro
Usuku Hiroki
Tokitsu Takanori
Fujisue Koichiro
Nishihara Taiki
Oike Fumi
Takae Masafumi
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Abstract
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Background/Aims: The Heart Failure Association (HFA)-PEFF score is recognized as a simple method to diagnose heart failure (HF) with preserved ejection fraction (HFpEF). This study aimed to evaluate the relationship between HFA-PEFF scores and cardiovascular outcomes in HFpEF patients.
Methods: A total of 502 consecutive HFpEF patients were prospectively observed for up to 1,500 days. Cardiovascular outcomes were compared between two groups of patients, defined by their HFA-PEFF scores: those who scored 2?4 (the intermediate-score group) and those who scored 5?6 group (the high-score group). Overall, 236 cardiovascular events were observed during the follow-up period (median, 1,159 days).
Results: Kaplan-Meier analysis showed that there were significant differences in composite cardiovascular events and HF-related events between the intermediate-score group and the high-score group (p = 0.003 and p < 0.001, respectively). Multivariate Cox proportional hazards analysis showed that the HFA-PEFF scores significantly predicted future HF-related events (hazard ratio, 1.66; 95% confidence interval [CI], 1.11 to 2.50; p = 0.014); receiver operating characteristic analysis confirmed this relationship (area under the curve, 0.633; 95% CI, 0.574 to 0.692; p < 0.001). The cutoff HFA-PEFF score for the identification of HF-related events was 4.5. Decision curve analysis revealed that combining the HFA-PEFF score with conventional prognostic factors improved the prediction of HF-related events.
Conclusions: HFA-PEFF scores may be useful for predicting HF-related events in HFpEF patients.
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KEYWORD
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Heart failure, Prognosis, Follow-up studies
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