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KMID : 0338420220370010127
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The Korean Journal of Internal Medicine
2022 Volume.37 No. 1 p.127 ~ p.136
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Clinical efficacy of adjuvant chemotherapy in stage IB (< 4 cm) non-small cell lung cancer patients with high-risk factors
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Choi Ju-Whan
Oh Jee-Youn
Lee Young-Seok
Min Kyung-Hoon
Shim Jae-Jeong
Choi Sue-In
Park Dong-Won
Park Chan-Kwon
Kang Eun-Joo
Yong Hwan-Seok
Shin Bong-Kyung
Kim Hyun-Koo
Lee Sung-Yong
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Abstract
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Background/Aims: Adjuvant chemotherapy is the standard of care for resected stage II?IIIA non-small cell lung cancer (NCSLC). The efficacy of adjuvant chemotherapy in stage IB (< 4 cm) NSCLC with high-risk factors is controversial.
Methods: This retrospective multicenter study included 285 stage IB NSCLC patients with high-risk factors according to the 8th edition tumor, node, metastasis (TNM) classification from four academic hospitals. High-risk factors included visceral pleural invasion, vascular invasion, lymphatic invasion, lung neuroendocrine tumors, and micropapillary histology patterns.
Results: Of the 285 patients, 127 (44.6%) were included in the adjuvant chemotherapy group and 158 (55.4%) were included in the non-adjuvant chemotherapy group. The median follow-up was 41.5 months. Patients in the adjuvant chemotherapy group had a significantly reduced recurrence rate and risk of mortality than those in the non-adjuvant chemotherapy group (hazards ratio, 0.408; 95% confidence interval, 0.221 to 0.754; p = 0.004 and hazards ratio, 0.176; 95% confidence interval, 0.057 to 0.546; p = 0.003, respectively). Adjuvant chemotherapy should be particularly considered for the high-risk factors such as visceral pleural involvement or vascular invasion. Based on the subgroup analysis, adjuvant chemotherapy should be considered when visceral pleural involvement is present, even if the tumor size is < 3 cm.
Conclusions: Adjuvant chemotherapy may be useful for patients with stage IB NSCLC with high-risk factors and is more relevant for patients with visceral pleural involvement or vascular invasion.
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KEYWORD
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Carcinoma, non-small-cell lung, Surgery, Chemotherapy, adjuvant, Risk factor
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