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KMID : 0338420220370030534
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The Korean Journal of Internal Medicine
2022 Volume.37 No. 3 p.534 ~ p.550
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Role of T cells in ischemic acute kidney injury and repair
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Lee Kyung-Ho
Jang Hye-Ryoun
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Abstract
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Ischemic acute kidney injury (AKI) is a common medical problem with significant mortality and morbidity, affecting a large number of patients globally. Ischemic AKI is associated with intrarenal inflammation as well as systemic inflammation; thus, the innate and adaptive immune systems are implicated in the pathogenesis of ischemic AKI. Among various intrarenal immune cells, T cells play major roles in the injury process and in the repair mechanism affecting AKI to chronic kidney disease transition. Importantly, T cells also participate in distant organ crosstalk during AKI, which affects the overall outcomes. Therefore, targeting T cell-mediated pathways and T cell-based therapies have therapeutic promise for ischemic AKI. Here, we review the major populations of kidney T cells and their roles in ischemic AKI.
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KEYWORD
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Ischemia, T-lymphocytes, Inflammation, Acute kidney injury, Reperfusion injury
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