|
KMID : 0338420230380040534
|
|
The Korean Journal of Internal Medicine
2023 Volume.38 No. 4 p.534 ~ p.545
|
|
|
The prognostic impact of reduced variant burden in elderly patients with acute myeloid leukemia treated with decitabine
|
|
Kim Mi-Hee
Kim Tae-Hyung
Ahn Seo-Yeon
Lee Jun-Hyung
Park Ju-Heon
Shin Myung-Geun
Jung Sung-Hoon
Song Ga-Young
Yang Deok-Hwan
Lee Je-Jung
Choi Seung-Hyun
Kim Mi-Yeon
Ahn Jae-Sook
Kim Hyeoung-Joon
Kim Dong-Hwan Dennis
|
|
|
Abstract
|
|
|
Background/Aims: We evaluated the role of next-generation sequencing (NGS)-based disease monitoring for elderly patients diagnosed with acute myeloid leukemia (AML) who received decitabine therapy.
Methods: A total of 123 patients aged > 65 years with AML who received decitabine were eligible. We analyzed the dynamics of variant allele frequency (VAF) in 49 available follow-up samples after the fourth cycle of decitabine. The 58.6% VAF clearance (Δ, [VAF at diagnosis ? VAF at follow-up] × 100 / VAF at diagnosis) was the optimal cut-off for predicting overall survival (OS).
Results: The overall response rate was 34.1% (eight patients with complete remission [CR], six of CR with incomplete hematologic recovery, 22 with partial responses, and six with morphologic leukemia-free status). Responders (n = 42) had significantly better OS compared with non-responders (n = 42) (median, 15.3 months vs. 6.5 months; p < 0.001). Of the 49 patients available for follow-up targeted NGS analysis, 44 had trackable gene mutations. The median OS of patients with ΔVAF ≥ 58.6% (n=24) was significantly better than that of patients with ΔVAF < 58.6% (n = 19) (20.5 months vs. 9.8 months, p = 0.010). Moreover, responders with ΔVAF ≥ 58.6% (n = 20) had a significantly longer median OS compared with responders with VAF < 58.6% (n = 11) (22.5 months vs. 9.8 months, p = 0.004).
Conclusions: This study suggested that combining ΔVAF ≥ 58.6%, a molecular response, with morphologic and hematologic responses can more accurately predict OS in elderly AML patients after decitabine therapy.
|
|
|
KEYWORD
|
|
|
Acute myeloid leukemia, Elderly patients, Decitabine, Allele frequency, Residual neoplasm
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|
|