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KMID : 0338420230380060844
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The Korean Journal of Internal Medicine
2023 Volume.38 No. 6 p.844 ~ p.853
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Impact of hepatitis B virus infection on the risk of gallbladder polyps: a cohort study
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Kim Nam-Hee
Kim Hong-Joo
Kang Ji-Hun
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Abstract
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Background/Aims : We aimed to determine whether hepatitis B virus (HBV) or hepatitis C virus (HCV) infection remains an important risk factor for gallbladder polyps (GBPs) in the current context of reduced prevalence of these infections.
Methods : The cohort included 392,913 asymptomatic adults who underwent abdominal ultrasonography (US).
Results : The prevalence of GBP sized ≥ 5 mm, ≥ 10 mm, and overall (< 5, 5?9 and ≥ 10 mm) was 2.9%, 0.1%, and 12.8%, respectively. The prevalence of hepatitis B surface antigen (HBsAg), hepatitis B core antibody (HBcAb), and hepatitis C antibody (anti-HCV) positivity was 3.2%, 26.7%, and 0.1%, respectively. The GBP risk was significantly increased in HBsAg-positive individuals, with an adjusted odds ratio of 1.66 (95% confidence interval, 1.49?1.85) for GBP ≥ 5 mm, 2.39 (1.53?3.75) for GBP ≥ 10 mm, and 1.49 (1.41?1.59) for overall, whereas there was no significant association between anti-HCV positivity and GBP risk. The GBP risk did not increase significantly in individuals who tested negative for HBsAg but positive for HBcAb.
Conclusions : The presence of HBsAg may be an independent risk factor for GBP development in the current context of a indecreasing prevalence of HBsAg positivity. A more comprehensive evaluation of GBP during abdominal US surveillance of HBsAg-positive individuals may be necessary.
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KEYWORD
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Hepatitis B virus, Hepatitis C virus, Gallbladder neoplasms
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