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KMID : 0338420230380060903
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The Korean Journal of Internal Medicine
2023 Volume.38 No. 6 p.903 ~ p.911
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Nailfold capillaroscopy findings of interstitial pneumonia with autoimmune features
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Lee Sang-Heon
Min Hong-Ki
Kim Se-Hee
Kim Young-Whan
Yoo Kwang-Ha
Kim Hee-Joung
Kim In-Ae
Kim Hae-Rim
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Abstract
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Background/Aims : We evaluated nailfold capillaroscopy (NFC) of interstitial pneumonia with autoimmune features (IPAF) and compared it with that of patients with connective tissue disease-interstitial lung disease (CTD-ILD) and idiopathic interstitial pneumonia (IIP).
Methods : Patients with newly diagnosed as ILD were evaluated using NFC. Baseline demographic, clinical, serological, and high-resolution CT findings were collected. NFC was semi-quantitatively scored with six domains ranging from 0 to 18. In addition, the overall patterns (scleroderma/non-scleroderma patterns) were determined.
Results : A total of 81 patients (31 with CTD-ILD, 18 with IPAF, and 32 with IIP) were included. The non-specific interstitial pneumonia pattern was the most common ILD pattern in the CTD-ILD and IPAF groups, whereas the usual interstitial pneumonia pattern was the most common in the IIP group. The semi-quantitative score of the CTD-ILD group was higher than that of the IPAF or IIP groups (5.8 vs 4.2 vs 3.0, p < 0.001, respectively). Giant capillaries and haemorrhages were more frequently present in the CTD-ILD and IPAF groups than in the IIP group. A scleroderma pattern was present in 27.8% of the IPAF group, whereas none of the IIP patients showed a scleroderma pattern.
Conclusions : NFC findings may be useful in classifying patients with ILD into CTD-ILD/IPAF/IIP.
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KEYWORD
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Interstitial pneumonia with autoimmune feature, Connective tissue disease, Idiopathic interstitial pneumonia, Nailfold capillary
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