|
KMID : 0357919760100010047
|
|
Korean Journal of Pathology
1976 Volume.10 No. 1 p.47 ~ p.52
|
|
|
Cantharidin-induced Hepatic Injury-Part Ⅰ : Reappraisal of Tissue Reaction Based on Hepatic Injury-
|
|
이제구(李濟九)/Chae Koo Lee
김용일(金勇一)/이정빈(李正彬)/Yong Il Kim/Jung Bin Lee
|
|
|
Abstract
|
|
|
Hepatic toxic injuries were induced in young male rats by subcutaneous injection of
Cantharidin and their histologic characteristics were summarized as follows ;
1) diffuse swelling of hepatocytes, periportal hepatocullular necrosis with smudging
and degranulation of cytoplasms in addition to focal spotty necrosis,
2) portal vein dilatation with swelling of its endothelial cells and leucocytic
margination, accompanied by periportal congestion, portal exudation and hemorrhage.
With the above histologic features, the main toxic mechanisms of Cantharidin to the
liver may be deduced as mixtures of vascular factor and direct toxic effect to the
hepatocytes.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|