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KMID : 0357919770110040301
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Korean Journal of Pathology
1977 Volume.11 No. 4 p.301 ~ p.308
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The Changes of Secretory Granule of Pancreatic Acinar cells Inducsd by Actinomycin D
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이동구(李東久)/Dong Koo Lee
정기환(鄭基煥)/손태중(孫泰重)/Ki Whan Chung/Tae Joong Sohn
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Abstract
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The author studied the changes of pancreatic acinar cells after actinomycin D
treatment to clarify the precise morphologic changes during secretory processes of the
recovery stage of injured cells. Rats were given intramuscular injection of 0.5μgm of
the drugs per gm of body weight. Animals were sacrificed on the next, second and fifth
days after injections and observed by the electron microscope.
The results were summarized as following:
The pancreatic acinar cells, on the next day after actinomycin D treatment showed
considerable loss of their secretory granules, shedding and destruction of membrane-
bound ribosomes, and fragmentation and distortion of lamella pattern of rER with
dilatation of their lumina. On the second day, rER remained in vesicular or vacuolar
shape and ribosomes were enormously increased in number. Golgi complex was mar-
kedly proliferated and active secretory granules were increased in number but most
were small.
On the fifth day, almost entire subcellular structures were returned to normal.
The results suggested that actinomycin D inhibited the secretory granule formation by
blocking the protein synthesis and these changes were progressively from the second
day and the recovery was completed on the fifth day.
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