KMID : 0357920090430020152
|
|
Korean Journal of Pathology 2009 Volume.43 No. 2 p.152 ~ p.156
|
|
The Expression of Transforming Growth Factor-¥â1 and ¥á-Smooth Muscle Actin is Increased in the Human Myxomatous Valve
|
|
Park Jeong-Hwan
Youn Ho-Joong Yoon Jung-Sook Park Chul-Soo Oh Soo-Sung Chung Woo-Baek Chung Jong-Won Choi Yun-Seok Lee Dong-Hyeon Oh Yong-Seog Chung Wook-Sung Hong Soon-Jo Sim Sung-Bo Lee Sun-Hee Lee Youn-Soo
|
|
Abstract
|
|
|
Background: In vitro experimental studies have reported that transforming growth factor-¥â1 (TGF-¥â1) stimulates the production of ¥á-smooth muscle actin (¥á-SMA) in porcine valves. However, the relation between TGF-¥â1 and ¥á-SMA in myxomatous valves has not been elucidated.
Methods: We classified 27 subjects into two groups: 1) myxomatous group (M:F=11:12, mean age=55¡¾15 years) and 2) rheumatic group (M:F=3:1, mean age=41¡¾17 years) according to preoperative echocardiographic and postoperative histologic findings. Twenty-seven valve specimens from the patients who underwent valve replacement were obtained. Tissue samples were analyzed by immunohistochemistry for TGF-¥â1 and ¥á-SMA. The positively stained areas were measured using an image analysis program (Image Pro-Plus 4.5), and then the TGF-¥â1 volume fraction (TGF-VF) and ¥á-SMA volume fraction (¥á-SMA-VF) were calculated.
Results: TGF-VF in myxomatous valves was higher than in rheumatic valves (2,759¡¾2,294 vs 864¡¾276, p=0.04). ¥á-SMA-VF in myxomatous valves was higher than in rheumatic valves (4,122¡¾2,275 vs 2,421¡¾844, p=0.002). There was a significant correlation between TGF-¥â1 and ¥á-SMA in myxomatous valves (r=0.38, p=0.04). There was no significant correlation between TGF-¥â1 and ¥á-SMA in rheumatic valves (r=-0.50, p=0.67).
Conclusions: TGF-¥â1 and ¥á-SMA may be related to the pathogenesis of myxomatous valves. The activation of TGF-¥â1 might increase the expression of ¥á-SMA in human myxomatous valves.
|
|
KEYWORD
|
|
Transforming growth factor-beta1, Alpha-Smooth muscle actin, Myxomatous valve
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|