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KMID : 0364819860240030263
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Korean Journal of Microbiology
1986 Volume.24 No. 3 p.263 ~ p.269
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Active Role of Oxygen on Penicillin Sensitivity and Formation of Membrane Protein in Esherichia coli K12
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Abstract
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1
Membrane proteins of facultatively anaerobic Escherichia coli K12 which was logarithmically grown in aerobiosis and anaerobiosis were compared on 5 to 10% liner gradient gel electrophoresis(Na Dod SOS PAGE). Membrane proteins were formed as different patterns between aerobiosis and anaerobiosis. Among them, 91Kdal protein (pbpla) was not synthesized in aerobiosis and 6OKdal protein (fts cluster), in anaerobiosis. Thereby cells cultured aerobically were differenciated as diversiform cell shape, comparing cells cultured anaerobically and the latter were resistant to penicillin G. Thus it is believed that in facultative anaerobes atmospheric oxygen regulated the synthesis of membrane proteins and even the expression of equivalent genes, and moreover alleviated the resistance to an antibiotic penicillin.
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