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KMID : 0368119920220010140
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Korean Circulation Journal
1992 Volume.22 No. 1 p.140 ~ p.145
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Short-term Aypolipidemic Effects of Pravastatin in patients with Hyperlipidemia
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배종화
강흥선/김권삼/김명식/송정상
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Abstract
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Background:
@EN Hyperlipidemia is the one of the major risk factors causing the atherosclerosis of coronary arteries. Treatment of hyperlipidemia with drugs has been confirmed the effects of therapy showing a decreased incidence of coronary artery disease.
Pravastatin is one of the new HMG-CoA reductase inhibitors and we studied the short-term hypolipidemic effects and safety of pravastatin in patients with hyperlipidemia.
@ES Methods:
@EN We studied 31 patients (7 males and 24 females ; range of age. 36-67 years) for 12 weeks whose plasma levels of total cholesterol were higher than 250mg% after one month period of diet therapy. Pravastatin was administered 10mg/day and
measured
lipid profiles at 4 week interval.
@ES Results:
@EN Pravastatin reduced the plasma total cholesterol from 286.2mg% to 212.3mg% 925.9%). the LDL-cholesterol from 204.2mg% to 143.6mg% (29.7%). the triglyceride from 226.0mg% to 161.4mg% (28.6%) after 12 weeks treatment. The HDL-cholesterol
increased
from 36.9mg% to 46.4mg% (20.5%) after pravastatin therapy. These changes were disclosed all statistically significant compared to baseline levels (p<0.01). The clinical and laboratory examinations before and after pravastatin treatment showed no
particular abnormal findings.
@ES Conclusions:
@EN These results suggested that short-term pravastatin therapy in patients with hyperlipidemia seems to be very effectve and safe.
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KEYWORD
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