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KMID : 0368119920220020269
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Korean Circulation Journal
1992 Volume.22 No. 2 p.269 ~ p.279
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the Onset of Coronary Atery Aneurysm and the Changes of T Cell Subsets and the Effect of High Dose Gammaglobulin Therapy in Mucocutaneous Lymph Node Syndrome
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김승환
김미령/오영균/박병규/도문홍/서봉관/염명걸
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Abstract
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We studied the onset of coronary artery aneurysm formation in 42 patients of Mucocutaneous lymph node syndrome (MCLS), the serial changes of T cell subsets. and serum immunoglobulin levels including IgG. IgA. IgM. in 13 patients among them during
acute
(before high dose γ-globulin therapy) and subacute phase (after γ-globulin therapy) to evaluate the role of the immunoregulatory abnormalities in coronary artery aneurysm formation.
@ES The following results are obtained:
@EN 1) The coronary artery aneurysm was found in 16 patients (38%). They were detected in between 6th and 13th day of illness with the mean of 8.8±2.1 day.
2) The total T lymphocyte (Tl), helper T lymphocyte (T4), and helper/suppressor ratio (T4/T8) decreased during acute phase.
3) Following γ-globulin therapy it showed a increase in T4. T8, and all immunoglobulins.
Above results showed that the most of aneurysms developed during acute phase and suppressed, rather than enhanced. T cell function significantly contributed to aneurysm formation. whereas high dose γ-globulin retarded or reversed this
suppression
which
would be one of mechanism of beneficial effect of γ-globulin in MCLS.
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KEYWORD
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