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KMID : 0368119920220020295
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Korean Circulation Journal
1992 Volume.22 No. 2 p.295 ~ p.300
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A Clinical Study on the Hypotensive Effect of Lisinopril
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강경원
최진원/김지훈/김정현/임헌길/이방헌/이정균
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Abstract
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Background:
@EN The hypotensive effect of the lisinopril, a long acting angiotensin converting enzyme inhibiter, was stduied.
@ES Method:
@EN 10mg of lisinopril was administered in 30 hypertensive Korean adults during twelve weeks after a week observation for washout with steptwise increments of the dose according to the patients blood pressure in every two weeks.
@ES Results:
@EN The supine blood pressures were decreased from 173.3±27.9/105.7±19.4mmHg to 131.8±23.1 mmHg/81.4±18.7mmHg at the end of twelve weeks durg therapy (p<0.05).
The standing blood pressures were also decreased conferrably and to the some lower levels.
Hematologic examination and blood chemistry revealed no discernible abnormal findings before and after the treatment.
During the period of the study a few probably drug-related symptom such as dry cough and dry mouth developed but not trouglesome enough to stop administering.
@ES Conclusion:
@EN Lisinopril 10mg once daily regiment is well tolerated and effective in the treatment of hypertensive patients.
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KEYWORD
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