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KMID : 0368119920220030488
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Korean Circulation Journal
1992 Volume.22 No. 3 p.488 ~ p.493
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Efficacy and Safety of nifedipine Gastrointesinal Therapeutic System(Adalat OROS) in patients with Mild to Moderate Essential Hypertension
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김대현
오세익/김용균/최석구/유원상
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Abstract
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Background:
@EN This study was designed to evaluate the antihypertensive efficacy and safety of nifedipine gastrointestinal system push-pull osmotic pump formulation in patients with mild to moderate essential hypertension.
@ES Methods:
@EN After 2 weeks placebo run-in period, nifedipine 60 mg was administered once daily for 8 weeks in thirty-two patients with mild to moderate essential hypertension.
@ES Results:
@EN At the end point of treatment, sitting blood pressure decreased as much as 33/16 mmHg in average and rewarded 88% of efficacy and 69% of normalization. The ambulatory blood pressure monitoring in 10 patients also revealed 11% decrease in 24
hr
mean
diastolic blood pressure and 32% decrease in % elevated blood pressure. The most frequent side reactions were constipation in 7 patients and polyuria in 6 patients which were tolerated during entire trial period. There were no significant changes
in
biochemical parameters and hematologic data, thus making the rate of safety 91% and overall rating of usefulness was 84%.
@ES Conclusion:
@EN Nifedipine GITS 60 mg once daily regimen is well tolerated and effective in the treatment of mild to moderate essential hypertension.
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KEYWORD
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