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KMID : 0368119920220040676
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Korean Circulation Journal
1992 Volume.22 No. 4 p.676 ~ p.682
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Clinical Effects and Safety of Delpril in Patients with Essential Hypertension
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오세익
정광호/김형곤/최석구/유원상
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Abstract
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BackgroundL
@EN To evaluate depressor effect and safety of delapril, a new ACE inhibitor, in Korean.
@ES Method:
@EN Thirty three patients, aged 37~69. with mild to moderate essential hypertension were first observed for 2 weeks with placebo followed by administration of 15mg of delapril twice daily for two weeks. then doubled dosage to 30mg b. i. d. and
combined
with 25mg of dihydrochlorothiazide if optimal BP were not obtaind at the end of 4th week. continued the same dose until the end of 10 week's trial period.
@ES Result:
@EN BP dropped 15/9mmHg in average at the end of 10th week rewarding 70% of cumulative effectiveness. Most frequent side reaction was dry cough. occurred in 9% of patients followed by chest tightness. headache, constipation and transient
elevation
of
GPT.
@ES Conclusion:
@EN Delapril 15~30mg twice daily as monotherapy or combined with diuretic is well tolerated and effective in the treatment of mild to moderate essential hypertension.
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KEYWORD
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