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KMID : 0368119930230010149
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Korean Circulation Journal
1993 Volume.23 No. 1 p.149 ~ p.153
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Effects of Amlodipine on Left Ventricular Diastolic Function in Patients with Essential Hypertension
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박종훈
곽병수/강승식/박기남/최용석/김백수/전은석
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Abstract
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Background:
@EN In previous study, hypertensive patients with left ventricular diastolic dysfunction showed delayed relaxation time intervals and increased relaxation nonuniformity of regional wall motion. In this point of view, the effects of amlodipine on
the
regional wall motion and mitral flow patterns were evaluated.
@ES Methods:
@EN Before and 32weeks after the antihypertensive medication of amlodipine. M-mode & Doppler echocarciogram were performed in 14 patients with moderate hypertension. We measured A2 to the peak thinning rate point of left ventricular (LV)
posterior
wall
[A2-(-) dpw/dt] and the peak lengthening rate point of mitral annulus [A2-dL/dt] on M-mode echocardiogram and we defined nonuniformity as the time interval, (-) dpw/dt-dL/dt.
@ES Results:
@EN 1) Mitral flow velocity E/A ratio was increased (0.95±0.4 vs 1.42±0.6, p<0.05) after amlodipine medication.
2) Heart rate and LV posterior wall thickness was decreased (79±9.3 vs 72±10.8 beats/min 10.7±1.5 vs 9.4±2.0mm, p<0.05 respectively).
3) Long axis relaxation was improved (A2-dL/dt; 165±44 vs 140±23msec, p<0.05) and nonuniformity index was decreased ((-)dpw/dt-dL/dt ; 63±49 vs 41±30msec p=0.07).
@ES Conclusion:
@EN Amlodipine improved E/A ratio of mitral flow (E/A ratio) in hypertensive patients with diastolic dysfunction, which could be attributed to the decreased heart rate, the decrease in wall thickness and the improvement in relaxation movement of
LV
long
axis.
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KEYWORD
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