Background:
@EN Systemic hypertension produces varying degree of LVH which is associated with increased cardiovascular morbidity. Previous studies have documented regression of LVH with various antihypertensives including calcium channel blockers, except
diuretics
and vasodilators. Recently echocadiographic assessment of the change of left ventricular mass(LVM) after antihyertensive therapy have been reported to offer prognostic cardiovascular information. The aim of this echocardiographic study is
determining
the influence of nicardipine, a calcium channel blocker, on the change of LVM in patient with essential hypertenison.
@ES Results :
@EN In the 15 patients treated for 6 months, systolic and diastolic pressure remained very significantly decreased compared with pressure before therapy(135±15mmHg vs 168±26mmHg, and 86±7mmHg vs 105±16mmHg, both P<0.01). Concomitantly body
LVM
and
LVMI decreased signiticantly (209±49g vs 235±71g, and 116±6g/㎡, both P<0.05). and no change was noted in left ventricular cavity size, demonstrating that LVM reduction was due to regression of hypertrophy.
@ES Conclusion:
@EN This study showed that nicardipine produced a significnat decrease in blood pressure, LVM, and LVMI over the 6 months period. And large and longterm controlled studies are needed for the clarification of the association between nicardipine
and
regression of LVH in hypertensive patients.
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