Background :
@EN In patients with variant angina, previous data have been inconclusive as to whether basal coronary artery tone is elevated at the spastic sites and nonspastic sites. The purpose of this study was to assess the basal coronary artery tone and
to
evaluate the responsive ness to acetylcholine and ergonovine in patients with variant angina.
@ES Methods :
@EN Basal coronary artery tone was assessed by obtaining the percent increase in coronary artery diameter induced by nitroglycerin in 66 patients with variant angina and 26 control subjects. We also compared the basal coronary artery tone and the
constrictive responses to acetylcholine and ergonovine between the 31 patients with variant angina whom spasm was provoked by the low doses of acetylcholine(Ach ; intracoronary. 20㎍) or ergonovine(Erg ; intravenous 50㎍)(Group 1) and the 35
patients
provoked by higher doses of acetylcholine(intracoronary, 100㎍) or ergonovine( intravenous cumulative dose of 350㎍)(Group 2).
@ES Results :
@EN Patients with variant angina whom spasm was provoked by low doses of acetylcholine and ergonovine, have a more tendency af combined fixed disease(mixed disease), multivessel spasm and igh disease activity.
Basal coronary artery tone at the spastic sites was significantly elvated in the Group 1 in whom spasm was provoked by low doses of acetylcholine and ergonovine than that in Group 2(44±17 vs 14±11%, respectively, p<0.05). Basal coronary artery
tone of
spasm-related artery, but not nonspasm related artery, at the non spastic sites was greater in the Group 1 than that in Group 2(26±14 vs 16±10%, respectively, p<0.05). In the patients with variant angina in whom spasm was provoked by higher
doses
of
acetylcholine or ergonovine, basal coronaryartery was comparable at the spastic and nonspastic sites and was not different from that in the control subjects. The magnitude of vasoconstrictive responses to acetylcholine and ergonovine, at the
nonspastic
sites, were also greater in Group 1 than those in Group 2 and the control groups(Ach ; 40±20 vs 26±11, 27±12% : Erg ; 37±18 vs 12±8, 13±10%, respectively, p<0.05).
@ES Conclusion :
@EN These findings suggest that elevated basal coronary artery tone of the spastic sites and nonspastic sites of spasm-related artery in patients with variant angina may be related to occurrence of coronary spasm.
|