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KMID : 0368119950250040830
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Korean Circulation Journal
1995 Volume.25 No. 4 p.830 ~ p.837
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Effect of Verapamil on the Cyclic Flow Reductions of Rabbit Carotid Stenosis
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최기준
한기훈/김상현/김효수/김철호/손대원/오병희/이명묵/박영배
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Abstract
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Previous studies have shown that experimental canine coronary or rabbit carotid artery stenosis that is assoiated with endothelial injury results in a typical pattern of blood flow characterized by gradual decreases in arterial flow followed by
restorations of flow to normal values. This pattern of flow, called cyclic flow reduction(CFR), is the consequence of recurrent platelet aggregation at the site of the stenosis and endothelial injury and subsequent dislodgement of the thrombus.
This study was designed to test the efficacy of verapamil in inhibiting in vivo platelet aggregation in a rabbit model of carotid artery stenosis and endothelial injury. Carotid blood flow was measured continuously with a electromagnetic
flowmeter
probe
that is positioned proximal to the constrictor. During placement of constrictor and angioplasty balloon, CFR developed in 8 of 20 rabbits with a mean frequency of 10.0±2.2 cycles/h. CFRs were observed for 30 min, and IV verapamil was
administered
till
declining of blood pressure(up to 100㎍/kg). After intravenous verapamil, the mean frequency of CFR insignificantly decreased to 8.7±2.1 cycles/h(p=ns). After 20mg/kg of aspirin were given intravenously, the CFR were abolished in 5 rabbits, the
mean
frequency of CFR decreased in 1 rabbit, and no significant change was observed in 2 rabbits.
It is concluded that verapamil is relatively ineffective in inhibiting in vivo platelet aggregation at doses that don't change hemodynamics significantly.
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KEYWORD
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