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KMID : 0368120010310050507
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Korean Circulation Journal
2001 Volume.31 No. 5 p.507 ~ p.511
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A Case of Acute Myocardial Infarction In Man Treated with Chemotherapy containing Doxorubicin for Non-Hodgkin Lymphoma
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김경호/Kyung Ho Kim
박우정/남택만/윤덕형/허필석/두영철/한규록/오동진/유규형/임종윤/이광학/이영/Woo Jung Park/Taek Man Nam/Duck Hyoung Yoon/Pil Seog Heo/Young Choel Doo/Kyu Rook Han/Dong Jin Oh/Kyu Hyeung Yoo/Jong Yoon Lim/Kwang Hak Lee/Young Lee
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Abstract
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Anthracyclines have been widely used in cancer therapy because of their efficacy in the treatment of various solid tumors and hem -atologic malignancy. Cumulative dose-related cardiotoxicity was a well-known toxicity of anthracyclines. Particularly, at
total doses of more than 550㎎/㎡, therapy with anthracyclines could produce irreversible cardiac injury. Anthracycline-induced cardiac toxicity was usually manifested by congestive heart failure or arrhythmia. In co- ntrast, acute myocardial infarction
is a rare event of anthracycline induced heart diseases. A 31-year-old man with non-Hodgkin lymphoma(NHL) and single cardiac risk factor, including smoking, was presented with chest pain after receiving 2nd CEOP-BLAM chemo therapy. An electrocardiogram
revealed ST segment elevation in inferior leads consistent with acute myocardial infarction. An echocardiogram revealed an ejection fraction of 60% and severe hypokinesia in inferior and anteroseptal wall. Three days later, coronary an giography
revealed 50% of luminal stenosis of right coronary artery (RCA) and near total occlusion with large thrombi in m-RCA. After balloon angioplasty and stent insertion, the patient was transferred to coronary care unit and continuous intravenous heparin
infusion was started. On the 10th days, the patient was discharged in good condition. Six months later, follow-up coronary angiography showed no significant lesion in right coronary artery. In a young man with NHL, we report an acute myocardial
infarction after 2nd course of CEOP-BLAM chemotherapy with a review of relevant literatures.
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