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KMID : 0368120040340060582
Korean Circulation Journal
2004 Volume.34 No. 6 p.582 ~ p.592
Diagnostic Value of Serum Cardiac Troponin T, Troponin I and CK-MB in Acute Kawasaki Disease
À±½Å¿ø/Yun SW
Abstract
Background and Objectives£ºKawasaki disease (KD) is a febrile acute multi-systemic vasculitis, which develops into carditis and coronary aneurysm. This study was performed to investigate cardiac troponin T (cTnT), troponin I (cTnI) and creatinine kinase-MB fraction (CK-MB) for diagnostic and prognostic value in acute KD before IVGG (intravenous gamma globulin).

Subjects and Methods£ºThe KD group comprised of 45 patients hospitalized between Jan. 2000 and Jul. 2003, with 25 non KD febrile illness subjects as controls. The KD group was subdivided into groups A (persistent normal coronary artery, n=20), B (abnormal coronary artery, n=19) and C (carditis, n=6) according to the initial echocardiography. The cTnT, cTnI and CK-MB levels were measured and compared.

Results£ºComparing the KD and control subjects, the cTnT (0.0101¡¾0.0030 vs. 0.0090¡¾0.0000 ng/mL, p=0.025) and cTnI (0.0662¡¾0.0581 vs. 0.0143¡¾0.0112 ng/mL, p=0.000) were significantly elevated in the KD patients. However, all the data were within normal reference ranges. In a comparison among the KD groups, the number of infants, total fever duration and IVGG re-treatment were significantly higher in group B (p=0.021, 0.046 and 0.007, respectively). There were no significant differences in the cTnT, cTnI and CK-MB levels between the 3 groups. The CK-MB and cTnI levels were slightly elevated in group B compare to groups A+C, but these were not statistically significant. The CK-MB, cTnT and cTnI levels were slightly elevated in those with cardiac abnormalities (groups B+C) compare to group A, but these were not significant. The cTnT and cTnI levels were significantly decreased in the subacute phase (p=0.034 and 0.000, respectively).

Conclusion£ºThe levels of cTnT, cTnI, CK-MB were not very useful tools for detecting and predicting subsequent cardiac damage in KD patients. However, the cTnI level appears to be a more sensitive marker than the cTnT or CK-MB levels in KD patients.
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