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KMID : 0368120040340090874
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Korean Circulation Journal
2004 Volume.34 No. 9 p.874 ~ p.882
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The Relationship of the Hypertension, Insulin Resistance, and Metabolic Syndrome in the Serum Uric Acid Level
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유태우/Yoo TW
성기철/김영춘/황상태/오세용/신헌섭/김병진/김범수/강진호/이만호/박정로/김향/이규백/이현영/유승호/금동극/Sung KC/Kim YC/Hwang ST/Oh SY/Shin HS/Kim BJ/Kim BS/Kang JH/Lee MH/Park JR/Kim H/Lee KB/Lhee HY/Ryu SH/Keum DG
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Abstract
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Background and Objectives：The relationship between serum uric acid and metabolic syndrome variables has not been reported in Korea. Therefore, whether the circulating levels of serum uric acid are independently related to hypertension, insulin resistance and the variables of metabolic syndrome were assessed.
Subjects and Methods：A total of 53,477 health screen examinees were enrolled and divided into four groups (Quartile 1：<4.2 mg/dL, Quartile 2：4.2-5.29 mg/dL, Quartile 3：5.3-6.29 mg/dL, Quartile 4：>6.29 mg/dL) according to their serum uric acid level. The blood pressure, lipid profiles, fasting plasma glucose, waist circumference, HOMA, high sensitivity CRP and apolipoprotein were compared between the four groups.
Results：There was a positive association between blood pressure and the serum uric acid level (p<0.001). After adjustment for covariates the prevalence of hypertension due to uric acid was 1.192 (95% CI, 1.038-1.368 p=0.013), and 1.408 (95% CI, 1.221-1.623 p<0.001) times higher in subjects in the third and fourth uric acid level quartiles, respectively, compared to the subjects in the first quartile. Insulin resistance and metabolic syndrome variables were positively correlated with the serum uric acid level. The number of metabolic syndrome variables was also increased with an elevated serum uric acid level.
Conclusion：Our study suggests that serum uric acid levels were independently associated with hypertension, insulin resistance and the variables of metabolic syndrome in the Korean population. Although the serum uric acid level was normal value, the risk of metabolic syndrome was increased with an elevated serum uric acid level. However, because of the cross-sectional nature of our study, these findings should be confirmed in prospective cohort studies.
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