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KMID : 0368120040340100983
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Korean Circulation Journal
2004 Volume.34 No. 10 p.983 ~ p.991
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Oral Everolimus Reduces Adventitial Cell Activation and Neointima Formation in Balloon-Injured Rat Carotid Artery
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문건웅/Moon KW
이종민/장기육/유기동/전두수/윤호중/정욱성/이만영/김종진/승기배/김철민/홍순조/Lee JM/Chang KY/Yoo KD/Jeon DS/Youn HJ/Chung WS/Lee MY/Kim JJ/Seung KB/Kim CM/Hong SJ
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Abstract
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Background and Objectives：Previous studies suggest that phenotypic conversion, proliferation and migration of adventitial fibroblasts after balloon injury have an important role in neointimal formation and vascular remodeling. The present study evaluated whether orally administered everolimus (a macrolide of the same family as sirolimus) reduces adventitial cell activation and neointimal formation in balloon-injured rat carotid arteries.
Materials and Methods：Oral everolimus (1.25 mg/kg/day), or a matching placebo, was administered daily to 30 rats by gavage, starting 3 days before balloon injury. The treatment effects were assessed 3, 7 and 14 days after injury.
Results：The oral everolimus group showed a significant reduction in adventitial cell proliferation at 3 days after injury and significant neointimal formation reduction compared to the control group at 7 and 14 days after injury (control group 0.06±0.01 mm2, everolimus group 0.01±0.01 mm2, p<0.01 and control group 0.28±0.06 mm2, everolimus group 0.08±0.03 mm2, p<0.01).
Conclusion：Oral everolimus reduces adventitial cell activation and neointima formation in balloon injured rat carotid arteries.
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