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KMID : 0368120040340121158
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Korean Circulation Journal
2004 Volume.34 No. 12 p.1158 ~ p.1166
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The Impact of Apolipoprotein A-I Polymorphisms on the Lipid Profiles in Middle Aged Healthy Men and Women
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문재연/Moon JY
조은영/김원호/최성훈/고영국/박현영/이종호/이종은/장양수/Cho EY/Kim WH/Choi SH/Ko YG/Park HY/Lee JH/Lee JE/Jang YS
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Abstract
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Background and Objectives：Apolipoprotein A-I is the major lipoprotein constituent of high density lipoprotein in plasma. In this study, the role of two polymorphisms in the apo A-I gene was investigated on the serum lipid profiles and apo A-I levels in healthy men and women.
Subjects and Methods：Blood samples were obtained from 417 subjects (M：F=169：248, mean age 47.2 years). The apo A-I genotypes were determined by SNP-IT assays using the SNPstream 25KTM system.
Results：The frequencies of the A allele at the XmnI restriction site and position -75 bp were 0.25/0.23 and 0.19/0.17 in men and women, respectively. A strong positive linkage disequilibrium (D’=0.990) between two polymorphisms was detected. In men, the A allele at the XmnI restriction site was associated with significantly lower levels of triglyceride (p=0.028) compared to the G/G subjects, but no significant associations were detected between the G-75A polymorphism and any of the lipid traits examined. In women, each A allele for the XmnI restriction site and -75 bp polymorphisms were significantly associated with higher levels of apo A-I (p=0.032 and p=0.012). In the multiple regression analysis, the HDL, being a current drinker and the A allele of the XmnI restriction site polymorphism were major determinants of the serum apo A-I levels in women (R2=0.272, p<0.05).
Conclusion：Our study showed that the A allele at XmnI restriction site in the apo A-I gene was associated with decreased triglyceride levels in men. Each A allele of two polymorphisms was associated with an elevated apo A-I level in women.
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