Àá½Ã¸¸ ±â´Ù·Á ÁÖ¼¼¿ä. ·ÎµùÁßÀÔ´Ï´Ù.
KMID : 0368120050350010030
Korean Circulation Journal
2005 Volume.35 No. 1 p.30 ~ p.36
Effect of Fibrate on Lipoprotein(a) Level in Hypertriglyceridemic Patients
±è¼ºÁø/Kim SJ
ÀÌ°æÀº/À̼ºÈ£/Á¤°©¼º/À̱¤Á¦/±èÅÂÈ£/°íÈ«¼÷/±èÄ¡Á¤/·ù¿Õ¼º/Lee KE/Lee SH/Jung KS/Lee KJ/Kim TH/Ko HS/Kim CJ/Ryu WS
Abstract
Background and Objectives£ºThe responses of lipoprotein (a) [Lp(a)] to lipid-lowering drugs are different from those of other lipids and lipoproteins. Most reports on the effect of fibrate on the Lp (a) level have only a few cases, with inconsistent results. This study was designed to evaluate the effect of fibrate on the Lp (a) level in hypertriglyceridemic patients.

Subjects and Methods£ºPatients with either a triglyceride (TG) level over 300 mg/dL or TG level over 200 mg/dL and a high density lipoprotein cholesterol level below 40 mg/dL, were enrolled. They were treated with either fibrate (Fibrate group, n=29) or general measures (Control group, n=29). Gender and age matched patients with hypercholeste-rolemia were adopted and treated with statin (Statin group, n=29). The lipid and lipoprotein levels were measured before and after the medication for 2 months.

Results£ºThe baseline Lp (a) levels were similar between the Fibrate and Control groups (p=0.19). Fibrate therapy increased the Lp (a) level from 10.3¡¾16.4 to 15.1¡¾15.2 mg/dL (p=0.003), but there were no changes in the Lp (a) levels in the Statin and Control groups. Before the treatment, the Lp (a) levels were negatively associated with the TG levels (r=-0.36, p=0.001). The relationship became weaker and insignificant after the medication. The more the TG level was decreased, the more the Lp (a) level was increased in all of the cases (r=-0.35, p=0.001) as well as in the Fibrate group (r=-0.46, p=0.013).

Conclusion£ºFibrate increased the Lp (a) level, and this elevation was associated with the reduction in the TG level. This finding might be related with a lesser cardioprotective effect of fibrate than that of statin in addition to the effect on the cholesterol level.
KEYWORD
FullTexts / Linksout information
 
Listed journal information
SCI(E) ÇмúÁøÈïÀç´Ü(KCI) KoreaMed ´ëÇÑÀÇÇÐȸ ȸ¿ø