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KMID : 0368120070370010027
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Korean Circulation Journal
2007 Volume.37 No. 1 p.27 ~ p.32
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Increased Inflammatory Markers and Endothelial Dysfunction are Associated with Variant Angina
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Cho Sook-Hee
Hwang Seon-Ho
Yoon Nam-Sik
Hong Seo-Na
Lee Sang-Rok
Kim Kye-Hun
Jeong Myung-Ho
Ahn Young-Keun
Cho Jeong-Gwan
Park Jong-Chun
Kang Jung-Chaee
Park In-Hyae
Park Hyung-Wook
Moon Jae-Youn
Kim Ju-Han
Hong Young-Joon
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Abstract
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Background & Objectives: Endothelial dysfunction and increased vascular inflammation may be associated with variant angina (VA). However, their exact roles remain to be clarified. The aim of the presents study is to investigate whether the level of inflammation markers and the flow-mediated dilation (FMD) are related to VA.
Subjects & Methods: The study included 46 patients (VA group: 53.9±12.0 years, 20 males) with positive spasm provocation tests and they were without significant coronary stenosis, and 14 patients (control group: 46.6±13.5 years, 7 males) with negative spasm provocation tests and they were without significant coronary stenosis. The clinical characteristics and inflammatory markers, including the high sensitive C-reactive protein (hsCRP) level, the monocyte count and the von Willebrand factor (vWF) level, and the FMD were compared between the two groups. The FMD and inflammatory markers were measured in the morning before performing the ergonovine provocation coronary angiogram.
Results: The level of vWF was significantly higher in the VA group than in the control group (166.5±41.9% vs. 118.0±65.3%, respectively, p=0.029). The FMD was significantly decreased in the VA group compared with the control group (9.2±4.3% vs. 12.4±4.2%, respectively, p=0.021). Nitrate-mediated dilation did not differ between the two groups. The levels of the monocyte count, hs-CRP and homocysteine were higher in the VA group than in the control group (554.7±261.0/mm3 vs. 440.7±136.0/mm3, respectively, p=0.039; 0.3±0.4 mg/dL vs. 0.1±0.1 mg/dL, respectively, p=0.029; 7.54±4.0μmol/L vs. 5.92±1.6μmol/L, respectively, p=0.033).
Conclusion: The results of this study suggested that increased inflammatory markers and endothelial dysfunction may be associated with variant angina.
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KEYWORD
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Angina pectoris, Inflammation, Endothelium
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