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KMID : 0368120070370060235
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Korean Circulation Journal
2007 Volume.37 No. 6 p.235 ~ p.243
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The Open Artery Hypothesis
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Kim Chul-Min
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Abstract
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There is considerable clinical and experimental evidence of the benefit of late reperfusion of infarct-related arteries, referred to as the open artery hypothesis, in patients with acute myocardial infarction who presented too late to salvage at-risk ischemic myocardium. In addition to myocardial salvage, reperfusion of the infarct-related artery prevents infarct expansion, reduces development of ventricular remodeling, and decreases ventricular arrhythmia. The Occluded Artery Trial recently answered a major question related to the open artery hypothesis in a high-risk, asymptomatic patient with an occluded infarct artery. In this review, clinical and experimental evidence of the benefit of the open artery hypothesis will be discussed.
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KEYWORD
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Myocardial infarction, Reperfusion, Ventricular remodeling
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