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KMID : 0368120070370060251
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Korean Circulation Journal
2007 Volume.37 No. 6 p.251 ~ p.257
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Leptin is Associated with Endothelial Dysfunction in Healthy Obese Premenopausal Women
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Kwon Ki-Hwan
Choi Kyung-Sun
Park Si-Hoon
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Abstract
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Background & Objectives: Previous studies have demonstrated that adipokines can have positive and/or negative effects on vascular function. In this study, we attempted to characterize the association of adipokines with endothelium-dependent vasodilation in healthy premenopausal women.
Subjects & Methods: Noninvasive pulse wave analysis coupled with provocative pharmacological testing with salbutamol was used to measure endothelium-dependent vasodilation in 60 healthy premenopausal women [37 obese women; body mass index (BMI) ≥25 kg/m2, 23 age-matched non-obese women; BMI<25 kg/m2]. The lipid profile, fasting insulin, glucose, and C-reactive protein (CRP) concentrations in each patient were assessed via standard laboratory techniques, and plasma concentrations of various adipokines, such as adiponectin, leptin, resistin and TNF-α, were measured via enzyme immunoassays.
Results: In the obese group, higher leptin concentrations were significantly associated with impairments in endothelium-dependent vasodilation (r=-0.371, p=0.005). This association remained significant, even after adjustment for other risk factors (β=-0.39, p=0.006). However, we determined that there was no significant correlation between endothelium-dependent vasodilation and these variables in the obese group and the control group.
Conclusion: Increased plasma concentration of leptin was associated with impairment in endothelial function in obese premenopausal women, regardless of the metabolic and inflammatory disturbances associated with obesity.
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KEYWORD
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Endothelium, Vascular, Leptin, Obesity
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