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KMID : 0368120090390020075
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Korean Circulation Journal
2009 Volume.39 No. 2 p.75 ~ p.78
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Abciximab (ReoPro)-Induced Thrombocytopenia Diagnosed Through Measurement of Heparin-Dependent Antibody
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Oh You-Jeong
Park Tae-Ho
Choi Yun-Jung
Cho Su-Hyun
Choi Jae-Hyuk
Lee Dong-Hyun
Park Sun-Yi
Cha Kwang-Soo
Kim Moo-Hyun
Kim Young-Dae
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Abstract
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Abciximab (ReoPro) is an extremely potent inhibitor of the glycoprotein IIb/IIIa receptor. Its main application is in the maintenance of coronary flow after suboptimal coronary intervention. Complications associated with this drug include bleeding and severe thrombocytopenia. We report a case of severe thrombocytopenia secondary to abciximab therapy for percutaneous coronary intervention in a 65-year-old woman suffering from an acute myocardial infarction. Her platelet count dropped to 1,000/mm3 7 hours after abciximab administration and improved with transfusion of 12 units of platelet concentrate the following day. The patient was diagnosed through measurement of heparin-dependent antibodies and readministration of heparin.
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KEYWORD
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Abciximab, Thrombocytopenia
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