|
KMID : 0368120090390040138
|
|
Korean Circulation Journal
2009 Volume.39 No. 4 p.138 ~ p.144
|
|
|
Association Between Inappropriateness of Left Ventricular Mass and Left Ventricular Diastolic Dysfunction: A Study Using the Tissue Doppler Parameter, E/E’
|
|
Lim Young-Hyo
Lee Jae-Ung
Kim Kyung-Soo
Kim Soon-Gil
Kim Jeong-Hyun
Lim Heon-Kil
Lee Bang-Hun
Shin Jin-Ho
|
|
|
Abstract
|
|
|
Background and Objectives : The structural significance of the inappropriateness of left ventricular mass (iLVM) is known to be an important prognostic factor for cardiovascular events; however, the functional changes associated with iLVM have not been established. This study was performed to determine if diastolic dysfunction is associated with iLVM using a tissue Doppler technique.
Subjects and Methods : Three hundred sixty consecutive subjects, including 221 hypertension patients from the echocardiography database, were analyzed. Regarding the appropriateness of left ventricular (LV) mass, an observed/predicted ratio of LV mass (OPR) >130% was defined as inappropriate. Echocardiographic parameters, including early diastolic peak velocity (E)/late diastolic peak velocity (A), deceleration time (DT), isovolumetric relaxation time (IVRT), and E/early mitral annulus velocity (E’), were compared between the appropriate LV mass (aLVM) group and the iLVM group.
Results: Among transmitral flow parameters, only the E velocity was negatively correlated with the OPR when adjusted for age (adjusted r=-0.107, p=0.04). Based on multiple regression analysis, the OPR (β=0.163, p=0.003), as well as age (β=0.286, p= 0.0001), systolic blood pressure (β=0.120, p=0.019), fasting blood glucose (β=0.098, p=0.042), and male gender (β=0.157, p=0.002) were independent factors determining E/E’. The cholesterol level was not an independent factor (β=-0.059, p=0.355). In the iLVM group (n=105), the adjusted E/E’ was higher than in the aLVM group (n=255; 11.7±3.4 vs. 10.8±3.1, p=0.02), while the peak E flow velocity was significantly lower than in the aLVM group (70.9±15.1 vs. 75.5±17.6, p=0.03).
Conclusion: Inappropriateness of LV mass is independently associated with increased E/E’. Thus, E/E’ may be a useful parameter for the evaluation of diastolic dysfunction.
|
|
|
KEYWORD
|
|
|
Hypertrophy, Left ventricle, Echocardiography
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|
|