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KMID : 0368120090390050180
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Korean Circulation Journal
2009 Volume.39 No. 5 p.180 ~ p.184
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The Effect of Telmisartan on Endothelial Function and Arterial Stiffness in Patients With Essential Hypertension
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Jung An-Doc
Cho Sang-Cheol
Kim Weon
Kim Wan
Hong Sung-Bum
Hwang Sun-Ho
Park Sang-Hyun
Park Jeong-Su
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Abstract
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Background and Objectives : Several studies have shown that angiotensin II receptor blockers (ARBs) improve endothelial function and arterial stiffness. Telmisartan is a highly selective ARB that activates peroxisome proliferator-activated receptor γ (PPARγ). The purpose of this study was to evaluate the effects of telmisartan, such as endothelial function, arterial stiffness, and insulin sensitivity, in patients with essential hypertension.
Subjects and Methods : Thirty-nine patients with essential hypertension were administered telmisartan (80 mg once daily) using an open-labeled and prospective protocol. The patients were examined before and 8 weeks after treatment to assess changes in flow mediated-vasodilation (FMD), pulse wave velocity (PWV), quantitative insulin-sensitivity check index (QUICKI), homeostasis model assessment (HOMA), and adiponection.
Results: The systolic and diastolic blood pressure (BP) decreased from 153±15 mmHg and 90±13 mmHg to 137±16 mmHg and 84±10 mmHg after telmisartan treatment, respectively (p<0.01). Telmisartan therapy increased the FMD from 7.6±3.5 to 9.0±2.8% (p<0.01). The following parameters of arterial stiffness were significantly improved after telmisartan therapy: brachial-ankle pulse wave velocity (baPWV), from 17.2±3.1 to 15.9±2.6 m/sec; heart-carotid PWV (hcPWV), from 9.7±1.8 to 9.0±1.9 m/sec; and heart-femoral PWV (hfPWV), from 11.3±1.9 to 10.7±1.9 m/sec (p<0.01). There were no changes in QUICKI, the HOMA level, and plasma adiponectin (p=NS).
Conclusion: These results suggest that telmisartan is effective in improving endothelial function and arterial stiffness in patients with essential hypertension.
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KEYWORD
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Angiotensin II type 1 receptor blockers, Endothelium, vascular, Arteriosclerosis
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