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KMID : 0368120090390120532
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Korean Circulation Journal
2009 Volume.39 No. 12 p.532 ~ p.537
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Characteristics of Myocardial Deformation and Rotation in Subjects With Diastolic Dysfunction Without Diastolic Heart Failure
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Jang Hee-Sang
Kim Jae-Hoon
Shin Seung-Min
Kang Hyun-Jae
Lee Bong-Ryeol
Jung Byung-Chun
Bae Byung-Seok
Kim Ki-Ju
Park Jung-Gil
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Abstract
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Background and Objectives : There have been very few pathophysiologic studies on isolated diastolic dysfunction. We hypothesized that the characteristics of isolated diastolic dysfunction would be located, on the clinical continuum, between those of a normal heart and diastolic heart failure.
Subjects and Methods: We enrolled 102 subjects who had no history of overt symptoms of heart failure and who had a left ventricular ejection fraction of more than 50%. They were examined for myocardial deformation and rotation using the two-dimensional speckle tracking image (2D-STI) technique.
Results: The circumferential strains and radial strain at the apical level (RSapex) were related to the ratio of the transmitral early peak velocity over the early diastolic mitral annulus velocity (E/E’). After adjustment for age, the RSapex showed a positive relationship with the E/E’ ratio; whereas, the circumferential strains did not. Instead, the circumferential strains demonstrated a significant correlation with age. Basal rotation and left ventricular (LV) torsion were also related to age, but had no relationship with the E/E’ ratio. However, as the E/E’ ratio value increased, systolic mitral annular velocity decreased.
Conslusion: Except for the RSapex, LV myocardial deformation and rotation did not vary with the degree of E/E’ ratio elevation when there was no associated diastolic heart failure. Additionally, in clinical situations such as isolated diastolic dysfunction, the advancement of age has a relatively greater influence on characteristics of LV myocardial deformation and rotation rather than on the E/E’ ratio.
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KEYWORD
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Heart failure, diastolic, E/E’ Ratio, Echocardiography, Doppler
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