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KMID : 0368120100400030131
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Korean Circulation Journal
2010 Volume.40 No. 3 p.131 ~ p.136
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Pulmonary Hypertension in Preterm Infants With Bronchopulmonary Dysplasia
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An Hyo-Soon
Bae Eun-Jung
Kim Gi-Beom
Kwon Bo-Sang
Baek Jae-Suk
Kim Ee-Kyung
Kim Han-Suk
Choi Jung-Hwan
Noh Chung-Il
Yun Yong-Soo
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Abstract
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Background and Objectives: With the increasing survival of preterm infants, pulmonary hypertension (PH) related to bronchopulmonary dysplasia (BPD) has become an important complication. The aim of this study was to investigate the characteristics and outcome of PH in preterm infants with BPD and to identify the risk factors for PH.
Subjects and Methods: We reviewed the records of 116 preterm infants with BPD cared for at a single tertiary center between 2004 and 2008.
Results: Twenty-nine (25%) infants had PH >2 months after birth. PH occurred initially at a median age of 65 days (range, 7-232 days). Severe BPD, a birth weight <800 g, long-term ventilator care and oxygen supplementation, a high ventilator setting, infection, and a patent ductus arteriosus (PDA) were related to PH based on univariate analysis (p<0.05). The infants who had longer oxygen supplementation were significantly more likely to have PH (odds ratio, 18.5; 95% confidence interval, 4.1-84.6; p<0.001). PH was improved in 76% of infants after a median of 85 days (range, 20-765 days). Four infants (14%) died. The death of 3 infants was attributed to PH.
Conclusion: BPD was frequently complicated by PH. Although PH resolved in the majority of infants, PH in preterm infants with BPD can be fatal. Regular screening for PH and adequate management are required.
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KEYWORD
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Hypertension, pulmonary, Infant, premature, Bronchopulmonary dysplasia
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