KMID : 0368120100400090454
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Korean Circulation Journal 2010 Volume.40 No. 9 p.454 ~ p.458
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Exercise Training Improves Age-Related Myocardial Metabolic Derangement: Proton Magnetic Resonance Spectroscopy Study in the Rat Model
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Choi Sang-Il
Chang Hyuk-Jae Chun Eun-Ju Cho Seong-Bong Kim Sang-Tae Yoon Yeon-Yee Chang Sung-A Kim Jae-Hyoung Kim Cheol-Ho Lim Tae-Hwan
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Abstract
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Background and Objectives: The objective of this study was to determine whether long-term exercise training will improve age-related cardiac metabolic derangement using proton magnetic resonance (MR) spectroscopy.
Materials and Methods: Young and old male Fischer 344 rats were assigned to sedentary controls groups {young control (YC) group-3 months of age: YC, n=10; old control (OC) group-22 months of age: OC, n=10}, and an exercise training group (OT, n=5). After 12-week of treadmill exercise training, MR spectroscopy at 4.7 T was performed to assess myocardial energy metabolism: measurements of myocardial creatine-to-water ratio (Scr/Sw) were performed using the XWIN-NMR software.
Results: Exercise capacity was 14.7 minutes greater in OT than that in OC (20.1¡¾1.9 minutes in OT, 5.4¡¾2.3 minutes in OC; p<0.001). The 12-week exercise training rendered the old rats a maximum exercise capacity matching that of untrained YC rats (17.9¡¾1.5 minutes in YC, 20.1¡¾1.9 minutes in OT; p>0.05). The creatine-to-water ratios in the interventricular septa of YC did not differ significantly from that of OT (0.00131¡¾0.00025 vs. 0.00127¡¾0.00031; p=0.37). However, OC showed significant reduction in creatine-to-water ratio compared to OT (0.00096¡¾0.00025 vs. 0.00127¡¾0.00031; p<0.001). Mean total creatine concentrations in the myocardium were similar between YC and OT (13.3 ¡¾3.6 vs. 11.5¡¾4.1 mmol/kg wet weight; p=0.29). In contrast, the mean total creatine concentration of OC was significantly reduced compared to OT (6.8¡¾3.2 vs. 11.5¡¾4.1 mmol/kg wet weight; p=0.03).
Conclusion: Our findings suggest that long-term exercise training in old rats induced prevention of age-related deterioration in myocardial metabolism.
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KEYWORD
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Magnetic resonance spectroscopy
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