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KMID : 0368120100400110558
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Korean Circulation Journal
2010 Volume.40 No. 11 p.558 ~ p.564
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Relationship Between Obesity and N-Terminal Brain Natriuretic Peptide Level as a Prognostic Value After Acute Myocardial Infarction
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Choi Sun-Kyu
Jeong Myung-Ho
Ahn Young-Keun
Cho Jeong-Gwan
Kang Jung-Chaee
Chae Shung-Chull
Hur Seung-Ho
Hong Taek-Jong
Kim Young-Jo
Seong In-Whan
Chae Jei-Keon
Rhew Jay-Young
Chae In-Ho
Cho Myeong-Chan
Bae Jang-Ho
Rha Seung-Woon
Kim Chong-Jin
Choi Dong-Hoon
Jang Yang-Soo
Yoon Jung-Han
Chung Wook-Sung
Seung Ki-Bae
Park Seung-Jung
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Abstract
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Background and Objectives: Recently, the prognostic value of N-terminal brain natriuretic peptide (NT-proBNP) in acute coronary syndrome has been demonstrated in many studies. However, NT-proBNP levels are influenced by various factors such as sex, age, renal function, heart failure severity, and obesity. NT-proBNP concentrations tend to decrease with higher body mass index (BMI). The aim of this study was to examine the influence of obesity on NT-proBNP as a predictive prognostic factor in acute myocardial infarction (AMI) patients.
Subjects and Methods: Using data from the Korea Acute Myocardial Infarction Registry (January 2005 to September 2008), 2,736 AMI patients were included in this study. These patients were divided into men (n=1,972, 70%) and women (n=764, 30%), and were grouped according to their BMIs. Major adverse cardiac events (MACE) during 1 year clinical follow-up were evaluated.
Results: NT-proBNP was significantly higher in lower BMI (p<0.001). Mean NT-proBNP levels of each obesity group were 2,393±4,022 pg/mL in the lean group (n=875), 1,506±3,074 pg/mL in the overweight group (n=724) and 1,100±1,137 pg/mL in the obese group (n=1,137) (p<0.01). NT-proBNP was an independent prognostic factor of AMI in obese patients by multivariative analysis of independent risk factors of MACE (p=0.01).
Conclusion: NT-proBNP is lower in obese AMI patients than in non-obese AMI patients, but NT-proBNP is still of independent prognostic value in obese AMI patients.
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KEYWORD
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Brain natriuretic peptide, Obesity, Myocardial infarction
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