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KMID : 0368120110410060342
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Korean Circulation Journal
2011 Volume.41 No. 6 p.342 ~ p.345
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QT Prolongation and Life Threatening Ventricular Tachycardia in a Patient Injected With Intravenous Meperidine (Demerol®)
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Song Mi-Kyoung
Bae Eun-Jung
Baek Jae-Suk
Kwon Bo-Sang
Kim Gi-Beom
Noh Chung-Il
Choi Jung-Yun
Park Sung-Sup
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Abstract
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QT prolongation is a serious adverse drug effect, which is associated with an increased risk of Torsade de pointes and sudden death. Many drugs, including both cardiac and non-cardiac drugs, have been reported to cause prolongation of QT interval. Although meperidine has not been considered proarrhythmic, we present a unique case of a 16-year-old boy without an underlying cardiac disease, who developed polymorphic ventricular tachycardia, ventricular fibrillation and QT prolongation after an intravenous meperidine injection. He had no mutation in long QT syndrome genes (KCNQ1,KCNH2, and SCN5A), but single nucleotide polymorphisms were reported, including H558R in SCNA5A and K897T in KCNH2.
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KEYWORD
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Long QT syndrome, Meperidine, Torsade de pointes
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